It’s funny how some of the best meals are the ones you throw together in a moment of inspiration, or maybe a bit of hunger-induced creativity. This recipe for High-Protein Spinach And Artichoke Chicken Casserole came about after a busy day when I was trying to use up some ingredients I had in the fridge.
I had some cooked chicken, fresh spinach, and artichoke hearts that had been sitting in my pantry for a while. I thought, “Why not make something hearty and healthy to feed the family tonight?”
I wanted to make sure it would be nutritious but still comforting—something my husband would enjoy. After all, with a busy schedule, finding a meal that checks all the boxes for protein, flavor, and ease is a must! This casserole was born from that idea. It’s creamy, cheesy, and packed with flavor from the spinach, artichokes, and garlic. When it came out of the oven, bubbling with golden cheese, I knew I had found a new favorite.
Now, this recipe has become a regular in our household. It’s a fantastic way to sneak in greens, and it’s one of those comforting meals that makes you feel like you’re getting a big hug, even on the busiest days. Best of all, it’s so easy to make, and you probably have most of the ingredients on hand already. If you’re looking for a quick, filling, and nutritious dish, this casserole might just be your new go-to.
Short Description
This High-Protein Spinach and Artichoke Chicken Casserole combines tender shredded chicken, vibrant spinach, and savory artichokes in a creamy, cheesy dish. It’s the perfect healthy comfort food for busy weeknights or casual gatherings.
Key Ingredients
- 1 lb chicken breast, cooked and shredded (about 2 cups)
- 1 bag (10 oz) fresh spinach, chopped (or frozen spinach, thawed and drained)
- 1 can (14 oz) artichoke hearts, drained and chopped
- 1 cup plain Greek yogurt (or sour cream for extra richness)
- 1 cup shredded mozzarella cheese, divided
- ½ cup grated Parmesan cheese
- 1 clove garlic, minced (or ½ teaspoon garlic powder)
- Salt and pepper, to taste
- Optional: Red pepper flakes for heat
- Cooking spray or olive oil for greasing the dish
Tools Needed
- 9×13-inch baking dish
- Large mixing bowl
- Cooking spray or olive oil for greasing
- Measuring cups and spoons
Cooking Instructions
Step 1: Preheat the Oven
Preheat your oven to 375°F (190°C). Lightly grease a 9×13-inch baking dish with cooking spray or olive oil to prevent sticking.
Step 2: Prepare the Filling
In a large mixing bowl, combine the shredded chicken, chopped spinach, chopped artichoke hearts, Greek yogurt, minced garlic, ¾ cup of the shredded mozzarella cheese, and all of the Parmesan cheese.
Season with salt, pepper, and red pepper flakes (if you’re using them). Stir everything together until it’s well mixed.
Step 3: Assemble the Casserole
Transfer the chicken mixture to the prepared baking dish, spreading it out evenly. Sprinkle the remaining ¼ cup of shredded mozzarella cheese over the top to give the casserole a bubbly, golden finish.
Step 4: Bake
Bake in the preheated oven for 25–30 minutes, or until the casserole is heated through and the cheese on top is melted and lightly golden. You can check for doneness by pressing gently with a spoon—the casserole should feel firm but soft in the center.
Step 5: Cool and Serve
Remove the casserole from the oven and let it cool for 5–10 minutes before serving. This allows the flavors to settle and makes it easier to slice. Enjoy warm, either on its own or paired with a light salad.
Why You’ll Love This Recipe
Packed with protein: The chicken and Greek yogurt make this casserole an excellent source of protein, which is essential for muscle repair and energy.
Healthy greens: Spinach and artichokes add nutrients like vitamins A and C, iron, and fiber without compromising on flavor.
Comforting and satisfying: This dish strikes the perfect balance between creamy, cheesy indulgence and a wholesome, healthy meal.
Versatile: It’s just as great for meal prep as it is for a weeknight dinner or a weekend family gathering.
Quick and easy: With minimal prep and just one baking dish, you can have a delicious meal ready in less than 45 minutes.
Mistakes to Avoid & Solutions
1. Casserole too dry?
If your casserole turns out dry, it might be due to overcooking or not using enough moisture. Make sure to bake it until just bubbly and golden. For extra richness, you can add a little more Greek yogurt or a splash of chicken broth.
2. Not enough flavor?
Make sure to season generously with salt, pepper, and garlic. If you want more flavor, you can add a squeeze of lemon juice or a dash of hot sauce.
3. Clumpy cheese?
To avoid clumpy cheese, be sure to stir the mixture gently and spread the cheese evenly across the top. Adding the cheese in layers will help it melt smoothly.
Serving and Pairing Suggestions
Serve as a main: This casserole is filling on its own and makes for a great main dish.
Side dish: It also works as a side dish to grilled meats or roasted vegetables.
Pair with a salad: A fresh, crisp salad with a light vinaigrette is the perfect complement to this rich casserole.
Pair with a glass of white wine: A light Chardonnay or Sauvignon Blanc would pair wonderfully with the creamy, cheesy flavors.
Storage and Reheating Tips
Storage: Store leftovers in an airtight container in the fridge for up to 3–4 days.
Reheating: To preserve the texture, reheat in the oven at 350°F (175°C) for about 15 minutes, or until warmed through. You can also reheat individual portions in the microwave for 1–2 minutes.
FAQs
1. Can I use frozen spinach instead of fresh?
Yes, frozen spinach works well. Just make sure to thaw and drain it thoroughly to remove any excess moisture.
2. Can I make this dish ahead of time?
Absolutely! You can assemble the casserole a day ahead and refrigerate it until you’re ready to bake it.
3. Can I swap the chicken for another protein?
Yes! You can use turkey, beef, or even tofu for a vegetarian version.
4. What’s the best way to freeze this casserole?
Freeze it before baking. Wrap it tightly in foil and store it in a freezer-safe container. When ready to bake, thaw in the fridge overnight and bake as instructed.
5. Can I add other vegetables to the casserole?
Yes, feel free to experiment with vegetables like mushrooms, bell peppers, or zucchini for added flavor and nutrition.
Tips & Tricks
Shred the chicken: For the best texture, shred your chicken with a fork or use a stand mixer to save time.
Make it spicy: Add a pinch of cayenne pepper or chili flakes to give the casserole an extra kick.
Use fresh garlic: Fresh minced garlic adds more depth of flavor than garlic powder, so I recommend using the real thing if you can.
Recipe Variations
Low-carb option: Skip the breadcrumbs and serve with a side of roasted cauliflower instead of rice.
Vegan twist: Swap the chicken for chickpeas and the Greek yogurt for a plant-based yogurt alternative.
Cheesy variation: Add some crumbled feta or goat cheese for a tangy twist alongside the mozzarella.
Final Thoughts
Cooking has always been a way for me to connect with family, and recipes like this casserole bring so much joy to my heart. It’s comforting to know that what I’m making for my loved ones is not only delicious but also full of nutrients. Every time I bake this dish, it feels like I’m carrying on a tradition of thoughtful, home-cooked meals—something I cherish deeply.
I hope this recipe becomes a favorite in your home too. It’s simple, satisfying, and can easily be adapted to fit your dietary needs. Whether you’re feeding a busy family or just looking for something easy and wholesome for yourself, this casserole is sure to deliver. Enjoy every bite!
High-Protein Spinach And Artichoke Chicken Casserole
Print ThisIngredients
- 1 lb chicken breast, cooked and shredded (about 2 cups)
- 1 bag (10 oz) fresh spinach, chopped (or frozen spinach, thawed and drained)
- 1 can (14 oz) artichoke hearts, drained and chopped
- 1 cup plain Greek yogurt (or sour cream for extra richness)
- 1 cup shredded mozzarella cheese, divided
- ½ cup grated Parmesan cheese
- 1 clove garlic, minced (or ½ teaspoon garlic powder)
- Salt and pepper, to taste
- Optional: Red pepper flakes for heat
- Cooking spray or olive oil for greasing the dish
Instructions
Step 1: Preheat the Oven
Set your oven to 375°F (190°C). Grease a 9×13-inch baking dish with cooking spray or olive oil.
Step 2: Make the Filling
In a large bowl, mix the shredded chicken, chopped spinach, artichoke hearts, Greek yogurt, garlic, ¾ cup mozzarella, and all the Parmesan. Add salt, pepper, and red pepper flakes (if using). Stir until well combined.
Step 3: Assemble the Casserole
Spoon the mixture into the baking dish and spread it evenly. Sprinkle the rest of the mozzarella on top.
Step 4: Bake
Bake for 25–30 minutes, until hot and the cheese is melted and golden. It should feel firm but soft in the center when pressed.
Step 5: Cool and Serve
Let it cool for 5–10 minutes before slicing. Serve warm—great on its own or with a simple salad.
